Some diabetes drugs can substantially increase the amount of fat inside our bones and thus the risk of bone fractures, warns a new study. The study also showed that exercise can decrease the volume of bone fat caused by high doses of the diabetes drug rosiglitazone, which is sold under the brand name Avandia.
rosiglitazone takes glucose out of blood to lower blood sugar and treat diabetes. But that glucose is then packaged into lipid droplets – fat. Other researchers showed that some of that fat is stored in tissue, such as belly fat.
The latest research conducted in mice showed that the drug also causes fat to be stored inside bone. Exercise might trigger marrow stem cells to create more bone cells instead of fat cells. Or perhaps exercise causes the body to access bone fat as fuel. It could be that bone fat is just another depot, a good energy store that allows bone cells to do what they need to do so bones become stronger.